Neurosarcoïdose : caractéristiques cliniques et paracliniques des atteintes du système nerveux central

Neurosarcoïdose : caractéristiques cliniques et paracliniques des atteintes du système nerveux central

Neurological localizations of central nervous system are heterogenous and rare. Our main objective is to describe the clinical, biological and MRI pattern of this population. We retrospectively included 118 patients : 38 with isolated neurosarcoidosis (NS), 80 with NS associated with systemic sarcoi...

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Bibliographic Details
Main Authors : Dos Santos Amélie (Auteur), Wiertlewski Sandrine (Directeur de thèse), Laplaud David-Axel (Président du jury de soutenance)
Corporate Authors : Université de Nantes 1962-2021 (Organisme de soutenance), Nantes Université Pôle Santé UFR Médecine et Techniques Médicales Nantes (Organisme de soutenance)
Format : Thesis
Language : français
Title statement : Neurosarcoïdose : caractéristiques cliniques et paracliniques des atteintes du système nerveux central / Amélie Dos Santos; sous la direction de Sandrine Wiertlewski
Published : 2020
Physical Description : 1 vol. (70 f.)
Note de thèse : Thèse d'exercice : Médecine. Neurologie : Nantes : 2020
Subjects :
Sarcoïdose
Système nerveux central > Maladies
Granulome
Épidémiologie
Diagnostic clinique
Thèses et écrits académiques
Related Items : Has reproduction: Neurosarcoïdose
Description
Summary : Neurological localizations of central nervous system are heterogenous and rare. Our main objective is to describe the clinical, biological and MRI pattern of this population. We retrospectively included 118 patients : 38 with isolated neurosarcoidosis (NS), 80 with NS associated with systemic sarcoidosis. The NS is the initial presentation in 77,9% of patients, with cranial nerves involvement (36,4%), medullary symptoms (22,8%) and seizures (21,2%). Patients were knowed to have systemic sarcoidosis in 20,6%. The diagnosis was concomittant of NS in 48,2% and post-NS in 52,8%. The ECA are increased in only 20,7%. The meningitis are present in 44,6% and hyperproteinorachia are frequent (69,5%). MRI results showed white matters abnormalities. The most useful treatment of NS is corticosteroids. Immunosupressive drugs are used in steroids resistant patients and to limit side-effects. Methotrexate and cyclophosphamid are frequently used with a good efficacy. Some study will be necessary to confirm efficacy and safety of anti-TNFa.
Variantes de titre : Neurosarcoidosis : clinical, biological and MRI presentation of central nervous system disease
Notes : Autre(s) contribution(s) : David Laplaud (Président du jury)
Bibliography : Bibliogr. f. 64-69, 84 réf.