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Synthesis and Characterization of Glycosides
There is no doubt that glycoside chemistry continues to be a dynamic and exc- ing ?eld related to organic chemistry. Within sugar chemistry, glycosides are of special interest not only because of the challenges represented by their synthesis and structural characterization, but also due to their imp...
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| Auteur principal : | |
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| Format : | Livre |
| Langue : | anglais |
| Titre complet : | Synthesis and Characterization of Glycosides / by Marco Brito-Arias. |
| Publié : |
Boston, MA :
Springer US
, [20..] Cham : Springer e-books Springer Nature |
| Accès en ligne : |
Accès Nantes Université
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| Note sur l'URL : | Accès sur la plateforme de l'éditeur Accès sur la plateforme Istex |
| Condition d'utilisation et de reproduction : | Conditions particulières de réutilisation pour les bénéficiaires des licences nationales : https://www.licencesnationales.fr/springer-nature-ebooks-contrat-licence-ln-2017 |
| Contenu : | Glycosides, Synthesis, and Characterization. O-Glycoside Formation. N-Glycosides. Nucleoside Mimetics. C-Glycosides. Glycoconjugates. Hydrolysis of Glycosides. Nuclear Magnetic Resonance of Glycosides. X-Ray Diffraction of Glycosides. Mass Spectrometry of Glycosides |
| Sujets : | |
| Documents associés : | Autre format:
Synthesis and characterization of glycosides |
| Résumé : | There is no doubt that glycoside chemistry continues to be a dynamic and exc- ing ?eld related to organic chemistry. Within sugar chemistry, glycosides are of special interest not only because of the challenges represented by their synthesis and structural characterization, but also due to their important biochemical re- vance, and hence their applications in a number of essential disciplines, such as pharmaceuticals, food, and biotechnology. Important biomolecules such as DNA and RNA, or cofactors such as ATP and NAD,aresomeofthenaturalglycosidicstructuresplayingkeyrulesatabioch- ical level. Also, a considerable number and variety of natural and synthetic gly- sides are being extensively used as antibiotics, antiviral, and antineoplasic agents. There are also a signi?cant number of chromophoric glycosides being used in molecularbiologyassubstratesfordetectionofenzymaticactivityofgenemarkers. Solid-phase oligosaccharide synthesis, despite the great progress recently - ported by different groups, continues to be a challenging task considering the diversity and complexity of glycosides, especially those present in cellular m- branes.However,basedonthesatisfactoryevolutionofthisapproach,itisexpected that many complex molecules will be prepared in just in the same way that sol- phase chemistry is currently used to prepare oligopeptides and oligonucleotides. The aims of this book are to prepare methods and strategies for the formation of glycosides,illustratedbythesynthesisofimportantbiologicallyactiveglycosides, andalsotopresentanoverviewofthebasictoolsneededforthecharacterizationof glycosides through NMR spectroscopy, X-ray diffraction, and mass spectrometry. From the overwhelming number of excellent articles related to glycoside ch- istry, it hasn t been an easy task to select those that are biologically important, and perhaps most importantly serve as didactic models for understanding more about the process of glycoside bond formation |
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| ISBN : | 978-0-387-70792-1 |
| DOI : | 10.1007/978-0-387-70792-1 |