Cancer
Thephosphatidylinositol-3-kinase/proteinkinase(PI3K/PKB)signalingpa- way also known as the survival or anti-apoptotic pathway plays an - portant role in controlling cell growth, proliferation and survival. Whatever the mechanism, the prevalence of PI3K/PKB signaling abnormalities in - man cancers an...
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Auteur principal : | |
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Format : | Livre |
Langue : | anglais |
Titre complet : | Cancer / edited by Robert H. Bradbury. |
Édition : | 1st ed. 2007. |
Publié : |
Berlin, Heidelberg :
Springer Berlin Heidelberg
, [20..] Cham : Springer Nature |
Collection : | Topics in medicinal chemistry (Berlin. Internet) ; 1 |
Accès en ligne : |
Accès Nantes Université
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Condition d'utilisation et de reproduction : | Conditions particulières de réutilisation pour les bénéficiaires des licences nationales : https://www.licencesnationales.fr/springer-nature-ebooks-contrat-licence-ln-2017 |
Contenu : | Overview. Anti-hormone Therapy: Principles of Endocrine Therapy of Cancer. Inhibition of Growth Factor Signaling by Small-Molecule Inhibitors of ErbB, Raf, and MEK. Farnesyl Protein Transferase Inhibitors: Medicinal Chemistry, Molecular Mechanisms, and Progress in the Clinic. Survival Signaling. Progress in the Development of Agents to Control the Cell Cycle. HDAC Inhibition in Cancer Therapy: An Increasingly Intriguing Tale of Chemistry, Biology and Clinical Benefit. Development of Angiogenesis Inhibitors to Vascular Endothelial Growth Factor Receptor 2 for Cancer Therapy. Novel Small-Molecule Inhibitors of Src Kinase for Cancer Therapy. Bcr-Abl Kinase Inhibitors |
Sujets : | |
Documents associés : | Autre format:
Cancer Autre format: Cancer Autre format: Cancer Autre format: Cancer |
Résumé : | Thephosphatidylinositol-3-kinase/proteinkinase(PI3K/PKB)signalingpa- way also known as the survival or anti-apoptotic pathway plays an - portant role in controlling cell growth, proliferation and survival. Whatever the mechanism, the prevalence of PI3K/PKB signaling abnormalities in - man cancers and its potential biological effects (e. g. , competitive growth advantage, evasion from apoptosis and therapy resistance) has suggested the potential use of PI3K/PKB pathway modulators as novel targeted therapeutic agents. Following this strategy, a number of compounds have demonstrated antitumor activity in preclinical and clinical settings by targeting directly or indirectly the different components of this pathway. This work covers - cent salient medicinal chemistry achievements in the identi?cation of these pathway modulators, updating recent reports on this class of potential c- cer drugs [1 4]. To help the reader, each section of this piece of work starts with a brief background to understand the target rationale and then moves on to the lead discovery, drug optimization, and clinical results stages as - propriate. A schematic representation of signaling through this pathway and the pathway components covered herein are shown in Fig. 1. Fig. 1 Schematic representation of signaling through the PI3K/PKB pathway 172 C. Garcia-Echeverria 2 Insulin-likeGrowthFactorI Receptor The Insulin-like Growth Factor-I Receptor (IGF-IR) is a member of the - sulin receptor family of tyrosinekinases. This transmembrane-spanning p- tein is composed of two ?-andtwo ?-subunits linked by disul?de bonds |
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Variantes de titre : | With contributions by numerous experts |
ISBN : | 978-3-540-33120-9 |
DOI : | 10.1007/978-3-540-33120-9 |